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"Everything should be made as SIMPLE as possible, but no simpler"

(A. Einstein)

About SIMPLE 1.0

Single-particle IMage Processing Linux Engine 1.0 (SIMPLE 1.0) does ab initio 3D reconstruction (programs cluster & origami), heterogeneity analysis (programs cluster, origami & cycler), and high-resolution refinement (programs align, reconstruct, automask & cycler).The SIMPLE back-end consists of an object-oriented numerical library with a single external dependency - the Fastest Fourier Transform in the West (FFTW). The SIMPLE front-end consists of a few standalone, interoperable components developed according to the 'Unix toolkit philosophy'. SIMPLE is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the license, or (at your option) any later version. SIMPLE is distributed with the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. You should have received a copy of the GNU General Public License along with this program. If not, see


SIMPLE 2.0 can be found here.

SIMPLE 2.1 can be found here.

SIMPLE 2.5 can be found here.